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burgdorferi DNA might sometimes be detected in synovial tissue after it is no longer found in joint fluid

Nevertheless, if its senolytic action has been demonstrated in several diseases such as osteoarthritis 15,16 as well as in neurodegenerative diseases 17 , the effect of ABT-263 is restricted to senescent cells from specific cell types 18 , leading to the necessity to identify new potential senolytics to target senescent cells in age-related diseases

However, other discussions focus on side effects that are otherwise not well established (e.g., menstrual cycle changes, increased fertility, depression, anxiety, flu vaccine sensitivities, myalgias), which merit further study

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