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In the SURMOUNT-1 trial, which enrolled 2,539 participants across tirzepatide doses of 5 mg, 10 mg, and 15 mg, musculoskeletal complaints were reported at rates of roughly 1-2%

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Early Evidence In the latest GLP-1 study 2025 , orforglipron showed early promise for adults with obesity and those living with type 2 diabetes, especially at the highest evaluated dose

Researchers utilize this mechanism to explore downstream effects on SIRT1 activation, which is a critical regulator of mitochondrial biogenesis, fat oxidation, and glucose metabolism