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This analysis revealed a 40% reduction in the replating capacity of end-stage clonogenic surviving cells that were treated 20 days earlier with sertraline in combination with 4 Gy RT compared to DMSO control (DMSO vs Sert 4 Gy, Sert vs Sert 4 Gy, 4 Gy vs Sert 4 Gy, p = 0.0008, p = 0.0278, and p = 0.0129, respectively) (Fig

[DOI] [PubMed] [Google Scholar] Bertrand N

After the first day the colonies change from a typical flat hPSC morphology, were one observes high nuclear to cytoplasmic ratio to domed, bright 3D colonies with no evidence of any cellular migration