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[13] Important limitations in the current evidence base include: Most studies measure acute GLP-1 responses to single meals rather than long-term effects Sample sizes are often small, and study populations vary widely The magnitude of GLP-1 increase from dietary interventions is substantially smaller than that achieved with pharmaceutical GLP-1 agonists Individual responses vary considerably based on genetics, baseline metabolic health, and gut microbiome composition From a safety perspective , natural approaches to supporting GLP-1 production through whole foods and lifestyle modifications are generally considered safe for most individuals

Lead author Professor John Deanfield (UCL Institute of Cardiovascular Science) said: Abdominal fat is more dangerous for our cardiovascular health than overall weight and therefore it is not surprising to see a link between reduction in waist size and cardiovascular benefit

The vast majority of weight loss, over 90 percent of the total, occurs within the first 12 months