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"It also restored mobility to osteoarthritic mice and significantly reduced their pain." As a proof of principle that this might also work in humans, the researchers transferred human tissue into mice that were bred to not reject the tissue, and were able to show that human skeletal stem cells could be steered toward bone development but stopped at the cartilage stage

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Therefore, although good validation results were obtained for CNCbl (details in the Method validation of the conversion SIDA method section), the conversion SIDA method developed and validated earlier cannot guarantee accurate determinations of total B12 contents in foods