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Powell-Wiley TM, Poirier P, Burke LE, Despres JP, Gordon-Larsen P, Lavie CJ et al (2021) Obesity and cardiovascular disease: a scientific statement from the american heart association

Under conditions of stress, Kelch-like ECH-Associated Protein 1 (KEAP1), which is a cytosolic inhibitor of Nrf2, is oxidized, leading to stabilization and translocation of Nrf2 into the nucleus, where the transcription factor activates expression of genes crucial to antioxidant defense [68]

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Medical Treatments : Options such as glutathione therapy or symptom-specific medications can address biochemical imbalances or other concerns