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The thinking was that rapid, substantial weight loss might thin the bones and raise the risk of fractures, particularly in people who are already vulnerable, like postmenopausal women." Surprising new research on semaglutide and fracture risk New research presented at an Endocrine Society meeting in Chicago found that people with type 2 diabetes who took semaglutide not only experienced more weight loss than those taking other diabetes and weight-loss medications, including Trulicity, Contrave and Qsymia, but they also had a 15 percent lower risk of bone fractures

Semaglutide injections are usually given in the abdomen, thigh or upper arm, each requiring specific needle considerations

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Int J Mol Sci 19(9):2712 Ringseis R, Keller J, Eder K (2013) Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies