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Mostly gastrointestinal nausea, vomiting, diarrhea, and constipation described as predominantly mild to moderate and dose-dependent, plus a modest heart-rate increase in the higher arms
Who Should Avoid GLP-1 Medications Not everyone is a good candidate for GLP-1 medications
Some patients need even more attention to lean-mass preservation, including: adults over 50 postmenopausal women patients with diabetes sedentary individuals people with low baseline muscle mass anyone consuming too little protein anyone losing weight quickly without exercise That risk-based framing is useful because it helps patients understand that muscle preservation is not an advanced niche concern
Well-manufactured lyophilized retatrutide typically shows water content between 1-3%
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