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Response can be weight change, it can be change in waist circumference or body composition (the ratio of fat mass to lean mass), Crotty says

Remove the medication, and, in the absence of meaningful ongoing lifestyle medicine intervention, weight regain will occur in the obese patient as sure as chronically high blood pressure will return in the hypertensive patient

This is not unlike muscle loss with bariatric surgery

In humans, plasma DPP-4 activity is higher in patients with non-alcoholic fatty liver disease irrespective of their glucose tolerance, whereas it was not elevated in patients with T2DM in whom liver disease had been excluded (84)