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Deep penetrating nevi consist of loosely organized nests of melanocytes with vacuolated pigmented cytoplasm and vesicular nuclei that often descend deeply into the reticular dermis, sometimes with a bulbous lower border (dumbbell shaped pattern)
While animal studies suggest safety, long-term human studies are lacking
Notably, RGD-GHK remained present in the epidermis and dermis layers of the skin after washing the skin surface and assisted wound closure in vivo , as expected
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