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In a widely cited New England Journal of Medicine trial, adults with overweight or obesity who used once-weekly semaglutide alongside lifestyle intervention lost substantially more weight than the placebo group

The primary aim was to evaluate the efficacy and safety of semaglutide compared with other anti-diabetic therapies in patients with T2DM as second-line in patients treated with metformin and as third-line in patients with metformin and SU

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