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Compared with mirabegron, another 3-adrenergic agonist, vibegron offers several clinical advantages, including lack of clinically significant CYP2D6 inhibition, no associated hypertension warning, and flexible administration (tablets may be crushed or mixed)

27 Under hypoxic conditions, intervened by hypoxia-inducible factor (HIF), there is a reduction in hepcidin expression, which promotes iron release

549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons