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Compounded semaglutide injections from licensed 503A pharmacies typically remain stable for 30 days when stored in the refrigerator at temperatures between 36F and 46F

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Why This Work Matters: This work demonstrates the strength of a 2D-LC-MS strategy, combining non-denaturing AEX with denaturing IP-RPLC-MS, for robust diastereomer separation and comprehensive impurity profiling supporting improved control and characterization of antisense, siRNA, and lipid-conjugated oligonucleotide therapeutics

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