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In the Phase 2 trial published in the New England Journal of Medicine (2023), retatrutide was administered as a once-weekly subcutaneous injection using a structured dose-escalation schedule

A randomized, phase 3, open-label trial comparing the effect of the addition of tirzepatide once weekly versus insulin lispro (U100) three times daily in participants with type 2 diabetes inadequately controlled on insulin glargine (U100) with or without metformin (SURPASS-6)

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