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[2] Nitric Oxide System & Endothelial Research Research applications include studies of: Endothelial nitric oxide synthase (eNOS) modulation through upstream kinase pathways Caveolin-1 (Cav-1) binding interactions with eNOS in cell culture Nitric oxide (NO) production mechanisms and microcirculatory effects in vascular models Platelet aggregation pathways in coagulation research Studies examine NO production mechanisms following cav-1 displacement in endothelial cell models and microcirculatory perfusion in preclinical research systems

FDA reviewed proposed uses involving cerebral ischemia, migraine and trigeminal neuralgia

DIFFERENTIAL DIAGNOSIS Hashimoto's thyroiditis is to be distinguished from nontoxic nodular goiter or Graves' disease

it is rare that any medical devices on the market that can specifically target only one delivery pathway