In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions
Analytical HPLC of preparative fractions and of the final product were performed on a C18 Infinity Poroshell 120 column (2.7 m, 100 3.0 mm) using an Agilent 1260 Infinity II series system equipped with a diode array UV detector using eluent III and eluent IV, rising linearly from 0 to 50% of eluent IV during t = 111 min at a flow rate of 1.2 ml min 1 at 40 C
Abbreviations AD: Alzheimers disease ANS: Autonomic nervous system BBB: Blood brain barrier CNS: Central nervous system GABA: Gamma aminobutyric acid NF-B: Nuclear factor kappa B NLRP3: Nod-like receptor pyrin 3 PD: Parkinsons disease ROS: Reactive oxygen species SAH: S-adenosyl-homocysteine SN: Substantia nigra References Aborode AT, Pustake M, Awuah WA, Alwerdani M, Shah P, Yarlagadda R, Ahmad S, Silva Correia IF, Chandra A, Nansubuga EP, Abdul-Rahman T, Mehta A, Ali O, Amaka SO, Zuiga YMH, Shkodina AD, Inya OC, Shen B, Alexiou A (2022) Targeting oxidative stress mechanisms to treat alzheimers and parkinsons disease: a critical review
Autoimmune-Mediated Pain: Conditions like rheumatoid arthritis where immune dysregulation drives inflammation and tissue damage may respond to immune-modulating peptides like Thymosin Alpha-1 and KPV
