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GHKCu has been shown to increase collagen and elastin, improve skin thickness, and reduce wrinkle volume, giving skin a firmer, more lifted, microsculpted look with consistent usewithout the irritation of traditional actives
They can function in different manners, including facilitating Fenton-like reactions, providing hydrogen peroxide, damaging the reducing system, and disturbing cellular communication (Fei et al., 2020)
The OPERA study (NCT03168139), a Phase 1/2 clinical trial, assessed the pharmacodynamics, safety, and efficacy of NOX-A12 both as a monotherapy and in conjunction with pembrolizumab in patients with metastatic microsatellite-stable (MSS) colorectal (CRC) and pancreatic (PaC) cancers, where PD-1 inhibitors have demonstrated restricted efficacy
Cells (2022) 11(6):932
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