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Therefore, results cannot be explained by light affecting depressive-like behavior through other pathways [i.e., without disturbing sleep or circadian rhythmicity, or through pathways unrelated to the SCN ( Clinical evidence supports that dysfunctions of the circadian timekeeping system are present in a variety of morbid clinical conditions, such as obesity, diabetes, hypercholesterolemia, cardiovascular diseases, and cancer (Figure 1)

P., Miyamoto, S

Symptoms typically worsen with standing and walking but improve with sitting or bending forward

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