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intramuscular route: count injections given Visit 4 (week 52) Anamnesis: record lifestyle habits and use of alcohol Symptoms: record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Questionnaires: EuroQoL-5D, satisfaction and preferences Assessment of haemogram and serum vitamin B12 concentration Assessment of adverse effects Assess adherence to treatment: oral route count number of vials used

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"What I'm looking at as a pharmacist, as a scientist, are clinical-based trials that are rigorous and demonstrate safety and efficacy," said John Herdig, chair of the board of the Collaborative for Evidence-Based Medicine, an organization that launched earlier this week