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Mechanistically, LONP1 promotes proliferation and migration of pulmonary artery smooth muscle cells by directly binding to and degrading mitochondrial pyruvate carrier 1 (MPC1), leading to pulmonary vascular remodeling and ultimately promoting the development of PH [76]

The Target of AnglV Analogs is Hepatocyte Growth Factor This Example shows that the novel angiotensin IV ligand Dihexa and its parent molecule Nlel -AnglV act through the HGF/c-Met receptor system

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