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parkeri survival in primary macrophages Many spotted fever group Rickettsia associate with leukocytes throughout their infectious lifecycles, including macrophages and neutrophils in the skin and in internal organs upon dissemination 7,39,40,41,42

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Furthermore, silica-based nanoparticles are biodegradable and biocompatible, allowing for informal functionalization with adjuvants or targeting ligands, enhancing their immunostimulatory potential in subunit vaccines [137]

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