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(Gastroenterology, 2008) reported PepT1-mediated uptake in human epithelial and immune cell lines with reduced NF-B activation and attenuated experimental colitis in mice

Cause : ATP7B gene mutation (chromosome 13)

The molecular mechanisms of silibinin-mediated antiproliferative effects are mainly via receptor tyrosine kinases, the androgen receptor, members of the signal transducer and activator of transcription (STAT) family, NF-kappaB (NF-B), and cell cycle regulatory and apoptotic signaling pathways in various cancer cells

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