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They feel flat, weak, and exhausted

Most cases resolved spontaneously, but the FDA is investigating further

Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025

"All four STEP trials did not include participants who had experienced major depressive disorder in the past two years or had bipolar disorder, schizophrenia, or other significant mental illness," Wadden told Newsweek