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5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that depletes NAD+ and promotes fat storageraising NAD+ increases mitochondrial respiration and thermogenesis

It will be shown that these various and non excusive susceptibilities may lead to a set of positive feedback loops that can become self-sustained, even in the absence of a persistent pathogen, but more efficiently in case of pathogen persistence