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There is evidence to suggest that PPA are formed in healthy individuals at therapeutic doses, particularly following repeated doses, suggesting that not all NAPQI is scavenged by glutathione even during therapeutic administration (see Fig

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Who should not rely on BPC-157 for alcohol protection: Anyone with diagnosed liver disease (cirrhosis, hepatitis, fatty liver disease) People with alcohol use disorder who need medical treatment, not peptide supplementation Anyone taking hepatotoxic medications (acetaminophen at high doses, certain statins, methotrexate) Individuals with bleeding disorders or on anticoagulants BPC-157 is not a substitute for medical care