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Therefore, design and development of efficient topical therapeutic agents would be promising in melasma management not only to induce optimum clinical response, but also avoid unwanted adverse drug reactions and relapse through the enhance in water solubility, increase the skin permeability, augment the photostability, and improve the dermal bioavailability of the loaded drugs

"Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes." Lancet Diabetes & Endocrinology, vol

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Diabetes 2, 4755