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Riboflavin status, measured by the functional biomarker erythrocyte glutathione reductase coefficient (EGRac), has been found to decrease only marginally, up to 10 % during pregnancy, however this was reported to occur together with a progressive increase in the prevalence of riboflavin deficiency, especially towards the end of the third trimester (Reference Heller, Salkeld and Krner63Reference Bates, Prentice and Paul65)

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Introduce one therapy at a time when possible so you can evaluate individual responses