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Rev Assoc Med Bras (1992), 2015

The ability to help a significant proportion of patients with T2D achieve normoglycemia without an increased risk of hypoglycemia represents a paradigm shift, moving the therapeutic goal from mere control towards potential disease remission

Moreover, they found that if in these cells the excess DA was transferred from the cytosol by transgenic overexpression of VMAT2which sequesters DA into synaptic vesiclesNM production was drastically reduced, providing evidence for the involvement of cytosolic DA in NM biosynthesis

Lowering blood sugar has also been seen to reduce the risk of heart attack, stroke, and heart-related death