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Elevated cortisol levels have been linked to increased neuroinflammation in conditions such as Alzheimers disease, in which inflammation is considered a feature of the disease process [312]

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Mitochondria are specialized membrane-bound organelles that play key roles in iron metabolism in that they synthesize heme, assemble iron-sulfur proteins, and are involved in the cellular iron regulation

Most studies have shown that the presence of HO-2 indicates a crucial role in male reproductive system and brain related diseases, although some studies have found HO-2 in the prevention of kidney injury and diabetes