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Disease-modifying therapies for osteoarthritis

It has been proven effective with low toxicity in improving depressive-like behavior by reducing brain iron levels and tau protein levels (Rao et al., 2020

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Morphologically, ferroptosis mainly manifests as obvious shrinkage of mitochondria with increased membrane density and reduction in or vanishing of mitochondrial cristae, which is a different process from other modes of cell death 1,3,4