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Even specific DPP4 inhibitors have potential side effects (gastro-intestinal, cardiovascular, infective, inflammatory, and allergic events) due to their prolonging the action of a number of neuropeptides and chemokines as well as to their non-enzymatic functions.

Tirzepatide is modified to: This dual-receptor design is what distinguishes Zepbound from single-pathway GLP-1 medications and has been associated with greater weight reductions in clinical trials

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