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This pricing structure created an opportunity for licensed compounding pharmacies to offer bioidentical tirzepatide at a fraction of the brand cost

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On the other hand, limitations in available GLP-1RA choices have led to selection biases, particularly in the early 2010s and in regions where access to other GLP-1RAs was relatively delayed

Doctors have been raising concerns for years that, while GLP-1 drugs have myriad benefits, they trigger such rapid weight loss that it's hard to preserve muscle or even have the energy to work out