clinical trials for glp-1 Glucagon-like peptide-1 receptor: mechanisms and advances in therapy History of GLP-1 Medications -

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and GIP receptors have also been demonstrated to activate phosphoinositide 3-kinase (PI3K) and its downstream effector Akt, which modulates mitochondrial function, metabolism, and cell survival

Quick Answer: GLP-1 medications may help reduce joint pain primarily through significant weight loss that decreases mechanical stress on weight-bearing joints, though they are not FDA-approved for this purpose

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