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Vitamin B12 IV therapy is very safe, however, as with any other medical procedure, individual intolerance and mild side effects may occur, including: Allergic reactions such as itching, rash, hives, and difficulty breathing

However, as we stated in the proposed rule, we have come to understand that if hospitals use substantially different lookback periods, particularly across multiple years, it could distort the allowed amounts, for example, because of pricing changes over time such as inflation, efficiencies, or the introduction of new products or services

Too-high levels of oxidative stress may be a precursor to multiple diseases

This low starting dose allows the body to adapt gradually before the dose is increased in a stepwise fashion over several months