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A 68-week clinical trial published in 2021 found participants taking semaglutide lost an average of 15.3 kg (roughly 34 pounds) over the testing period, compared to the placebo group that lost an average of 2.6 kg (roughly 6 pounds)

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Eur Respir J 2017;49:1601162

One such example is glucagon-like peptide 1 (GLP-1) (3.3 kDa), a small peptide hormone with a plasma half-life of only two minutes due to enzymatic degradation by dipeptidyl peptidase-4 (DDP-4) in the blood and rapid excretion through the kidneys 16,17,18,19