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The US Food & Drug Administration (FDA) removed tirzepatidethe active ingredient in the weight loss drug Zepbound from its shortage list last year

These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione

Journal of Clinical Endocrinology & Metabolism .Read source (1993)