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15% from injections in clinical trials.) Potential side effects and risks of oral semaglutide The most common side effects of oral semaglutide include: Stomach pain Diarrhea Decreased appetite Vomiting Typically, these gastrointestinal side effects are most common when starting treatment and when increasing your dose

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As a result, eating a restrictive diet, such as a strict vegetarian or vegan diet, can lead to B12 deficiency

Formulations/administration route Most GLP-1s are administered via subcutaneous (under the skin) injection