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MeCP2 is the highest expressed nuclear protein in the brain among various tissues [56], and 7 times higher in neurons than glia [57]

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The focus is on GSK3-DRP1 signalling, a critical pathway regulating mitochondrial dynamics, including fission and fusion processes [7]

Moreover, existing data indicate that single-target GLP-1RAs such as SEMA and liraglutide show promising capabilities for fibrosis improvement, and the initial success of the dual agonist tirzepatide suggests potential benefits of dose titration therapy in the monotherapy management of MASLD