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TBC1D9B was particularly interesting because of its putative function as a GTPase-activating protein (GAP) and its hypothesized role in endo-lysosomal trafficking, possibly by modulating the function of RAB proteins (i.e., RAB11A) 38 and/or related small GTPases

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Ipamorelin acts through GHS-R1a, whereas compounds such as CJC-1295 and Sermorelin target the growth hormone-releasing hormone receptor (GHRHR)

87,283,284 The interaction between HMGB1 and RAGE amplifies the inflammatory cascade, contributing to cell apoptosis and endothelial dysfunction, resulted to CVD or CKD