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More chronic, placebo-controlled human studies are required to evaluate not only the bioavailability and efficacy of various polyphenol formulations and delivery systems but also to establish standardized dosages, monitor potential side effects, and assess inter-individual differences in responses due to genetics and gut microbiota composition (126, 127)

Nutraceuticals with a clinically detectable blood pressure-lowering effect: a review of available randomized clinical trials and their meta-analyses

However, the mechanisms by which SGLT2 inhibitors exert these benefits beyond glucose-lowering are not fully understood

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