Gq activates phospholipase C (PLC), leading to hydrolysis of phosphoinositol diphosphate (PIP2) into products like IP3 and DAG, resulting in elevated Ca levels
According to updated guidelines, patients should stay on a clear liquid diet 24 hours before surgery instead of discontinuing the GLP-1 drug, and the medical team should perform an ultrasound before surgery to assess stomach contents in high-risk patients
The mechanism likely involves rapid shifts in blood glucose levels, fluid changes from reduced eating and medication effects on the gastrointestinal system, or dehydration from inadequate fluid intake during weight loss
Maas MN, Hintzen JCJ, Porzberg MRB, Mecinovi stands J, Trimethyllysine JCJ, Porzberg MRB, Mecinovi stands J