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Vitamin D's role in perimenopause extends beyond bone: its receptors in pancreatic beta cells, vascular smooth muscle, and brain neurons make deficiency a multisystem liability during the hormonal transition

The mechanisms of the beneficial activity of curcumin on the nervous system include limiting the production of ROS and reactive nitrogen species (RNS), and counteracting the decreased activity (SOD) and level (GSH) of antioxidants [65]