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13 However, while these approaches can provide benefit in the treatment of indications, there are limitations: fasting is often required before and after drug administration (such as with the GLP-1 receptor agonist Rybelsus, 14 which contains salcaprozate sodium (SNAC) as the PE) and some have raised safety concerns due to the potential for irreversible intestinal epithelium damage

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Targeting ferroptosis: The recognition that iron-mediated oxidative damage (ferroptosis) plays a role in POCD has led to exploring iron chelators