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Semaglutide causes significant appetite suppression, which leads to reduced caloric intake, which can deplete NAD+ levels, which reduces cellular energy, which contributes to GLP-1 fatigue

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However, increasing NAD+ levels in the body can offer many benefits, including boosted energy, reduced inflammation, supported cognitive function, increased immunity, and enhanced mental well-being

FIGURE 3 To better understand the biological processes and signaling pathways modulated by anwuligan, GO and KEGG functional enrichment analyses were performed on the 1,638 DEGs