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It does not yet provide long-term cardiovascular outcome data or real-world effectiveness outside controlled trial conditions
11 GSH depletion and the subsequent low stores of protein thiol result in both calcium release from intracellular stores and inhibition of calcium extrusion, producing a marked increase in cytosolic calcium concentration, which triggers cytotoxicity
In contrast, cumulus granulosa cells show elevated expression of genes involved in oocyte communication and matrix remodeling, including GJA1 (gap junction protein alpha 1), HAS2 (hyaluronan synthase 2), and PTGS2 (prostaglandin-endoperoxide synthase 2) [122, 194, 195]
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