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In trials for OSA (TRIUMPH1 and TRIUMPH2 OSA baskets), the primary endpoint is the change in the ApneaHypopnea Index (AHI) (number of apnea and hypopnea events per hour), and secondary endpoints include PatientReported Outcomes Measurement Information System SleepRelated Impairment (PROMISSRI), percentage of participants with a 50% decrease in AHI, and hypoxic burden as assessed by % change in Sleep ApneaSpecific Hypoxic Burden (SASHB)

Artioli et al

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Until now, it was believed that pancreatic alpha cells were only able to produce glucagon, a hormone that helps to raise blood sugar levels when our bodies require energy, for example, during fasting or exercising