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Early trials, concerned about possible cardiac safety issues, were designed to ensure that GLP-1 use did not negatively impact cardiovascular outcomes

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In July 2024, Pfizer announced that based on results from the ongoing pharmacokinetic study (NCT06153758), the company selected its preferred once-daily modified release formulation for danuglipron , an oral glucagon-like peptide-1 (GLP-1) receptor agonist

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