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Certain gut bacteria, including Bacteroides , Bifidobacterium , Prevotella , Faecalibacterium , Lactobacillus , and Parabacteroides , ferment indigestible polysaccharides into short-chain fatty acids (SCFAs)such as butyrate, acetate, and propionatewhich enhance epithelial barrier integrity and reduce gut permeability, thereby preventing microbial translocation to extraintestinal tissues [100, 101]

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Saxenda is a GLP-1 receptor agonist that slows gastric emptying and reduces appetite, licensed for weight management in adults with obesity or overweight with comorbidities