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Studies have demonstrated that TBI-associated mRNA signature and enhanced type 1 interferon signaling are apparent in cortical microglia after TBI (Witcher et al., 2021)

However, it is well known that such retrospective observational epidemiological studies on drug effects may be influenced by two main limitations, protopathic bias (i.e., dermatologists were treating presumed psoriatic arthritisPsA) and confounding by indication (i.e., dermatologists tended to use more TNF inhibitors in suspected PsA compared to IL-12/23 inhibitors) [5]