81 Cytochrome P450 represents a large family of enzymes responsible for catalyzing various oxidation-reduction reactions, present in all mammalian tissues, with the most reactive forms found in the liver, kidney, and small intestine
It participates in redox signaling pathways by modulating the balance between reactive oxygen species and cellular defense systems
However, large amounts of heavy metals can be toxic to the body and the environment
Immunofluorescence staining Sections were stained for keratin 19 (K19) (Developmental Studies Hybridoma Bank, TROMAIII), Zonula occludens-1 (ZO-1) (Abcam, ab96587), Vimentin (Abcam, ab92547), and 4,6-diamidino-2-phenylindole (DAPI) (D1306, Invitrogen), as previously described 67